Resistance development is common, so switching up chemos is what is usually rec. Get more opinions if you can. My sister is on her 4th type of chemo. She also had y-90 radioembolization to liver tumors which seems to have stabilized/are necrotic and she had external beam radiation to a subcutaneous and a rib bone met. Next is high frequency focused ultrasound (HIFU) to rib bone mets. Meanwhile on irinotecan for chemo. It’s hard to know which chemo will work and for how long. Side effects of low blood cell counts and neuropathy can sometimes halt, delay or reduce dosage of a specific chemo regimen. Its good to have a team of docs who work together and plan ahead for next course of action. Best to your dear wife.
Willow