Discussion Board Forums Good News / What’s Working Update on NIH trial

Viewing 13 posts - 1 through 13 (of 13 total)
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    Posts
  • #78694
    darla
    Participant

    All this coverage. It’s totally AWESOME!!!!!! :)

    #78693
    gavin
    Moderator
    #78692
    mbachini
    Moderator

    Thanks you guys for posting these…I am so glad they showed the CT of the tumor reduction! Every time I see it…I get goose bumps! Thanks for all the support!
    Melinda

    #78691
    marions
    Moderator

    Oh, and she is in the New York Times as well. I posted it under a different thread. Famous is right and for all the good reasons.
    Hugs,
    Marion

    #78690
    jscott
    Member

    You are famous!

    The article is behind a paywall, but here is a nice write-up of the results.

    http://medicalxpress.com/news/2014-05-woman-cancer-highlights-treatment.html

    Jason

    #78689
    gprins
    Member

    Well done Ms Bachini!! I saw the manuscript in the new issue of Science today and thought- “yes I know that case. She’s been sharing her updates all along.” What a major wonderful contribution you have made to science and a more effective Tx option for this disease in the future. You’re a rock star!!!!

    #78688
    marions
    Moderator

    You are welcome, dear Judy.

    #78687
    judym
    Member

    Thanks Marion.

    #78686
    marions
    Moderator

    Judy….I believe this is the clinical trial:
    http://www.clinicaltrials.gov/ct2/show/NCT01174121

    You might want to reach out to Melinda via her personal e-mail:
    click on her name in the signature box
    scroll down to her e-mail.
    Hugs,
    Marion

    #78685
    judym
    Member

    Melinda, do you have the name/number of your clinical trial? Was it just for the lungs or were you treated for CC? I am very interested to learn more. Who was your doctor? Thanks, Judym

    #78684
    darla
    Participant

    Melinda,

    Thanks for the update. Sounds like you are doing well. Looking forward to hearing more good news after your check up on Thursday.

    Love & Hugs,
    Darla

    #78683
    marions
    Moderator

    Melinda…thanks for posting it twice. I have responded to you on the other thread.
    Hugs,
    Marion

    #9402
    mbachini
    Moderator

    Hi everyone!

    I am so sorry it has been so long since I have posted…..no good excuse. I will do my best to catch you all up on what has been happening.

    I believe the last I posted was that my tumors were just starting to grow after a great year on this trial…..last August when I went in for my checkup the team of doctors deemed progression and became urgent to repeat the TIL protocol for me. They explained that my DNA mutates somewhere around 20 times before it turns to cancer and that they had identified a specific T cell of mine that recognized a specific mutation. I am sure that I am probably not explaining this exactly as they did, but this is how my simple mind understood it. This was discovered after my first treatment. They wanted to retreat me as soon as possible and I was all for it!!!

    In September 2013, they removed 3 of the larger tumors from my right lung this time….now I have matching scars on each side:) They harvested the lymphocytes and grew them in the lab again for 3 weeks, specifically growing the cell that is reactive to my tumor.

    In October my husband and I returned to NIH for treatment. I felt stronger going into this treatment than the first but I have to admit it was harder this time around…..the week of chemo to suppress my immune system sucked as usual but was tolerable. This time I received 127 BILLION cells back into me with about 90-95% of them being that “special T cell”…..compared to the 42 Billion the first time with only about 25% of them being that ” special cell”. I again only made it through 4 doses of IL2, which hit me harder this time around. IL2 helps to facilitate the cells to be active or something like that, all I know is it gave me some pretty comical hallucinations and sent my creatinine through the roof. It also was harder this time just because of the number of cells infused. It was a huge immune response…which is what makes you feel yucky when you are sick. I made it, and my counts came back enough to go home on November 8th. Recovery was a bit harder this time but within 2 weeks I was up and at it and each day got a little better.

    My first checkup was December 5th, 2013….with GREAT results. My liver tumors had shrunk and most of my lung tumors as well….they estimated about a 15% overall shrinkage in the first month. I am due to head back to NIH in the morning and I will have results of my second checkup on Thursday. I am expecting great results again. I have felt awesome, even skied on Christmas day and kept up with the kids!

    I invite you all to look at my caring bridge site http://www.caringbridge.org/visit/melindabachini ….I tried to document this treatment as best I could this time around.

    I will update with results this week….you are all always in my thoughts and prayers …..hugs, Melinda

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