Dearest Sally, ONLY if your Sister is ready to concede, and I think anyone would know she gave the fight her all, only then would I let it be. BUT IF she feels she has any fight left I would get another opinion post haste. The ONC doesn’t know what kind of chemo to use? Wonder if he tried to find out. Did he recommend Hospice? Is he going to control pain? Sally, don’t forget I have that list of signs of what to expect at the end of the journey and if you like just slip me an email and I will send them to you. My [prayers go out to you Sister and Family what ever the decision may be.