What next after Agio-120

Hi Daisy,

I think the doctors may be recommending Folfiri.  Folfiri is a chemo combination of fluorouracil (also called 5FU) with irinotecan, plus folinic acid (leucovorin) which is a vitamin that helps the 5FU bind better to cancer cells.  This combo is often used for colorectal cancers.  It has shown effectiveness with cholangiocarcinoma and is sometimes used as a second-line treatment.  The 5FU can be administered through a take-home pump.

If you search Folfiri on our board you will pick up a lot of posts about Folfirinox which is a different chemo combo, so it might in this case be as helpful to search the internet for information on Folfiri.

Do you and your mother see pursuing another clinical trial as an option?  I think at the moment clinical trials offer more opportunities for cholangiocarcinoma patients to try immunotherapies, including in combination with standard chemos.

Regards, Mary

Hi Daisy,

It is great to hear that your mother had such a good and long run with the AG-120 trial.  I hope her next treatment proves just as effective or better.

I looked through the board information, and there seems no pattern to next treatment after AG-120.  I found one person treated with dasatinib, and another with Keytruda, and another with a standard chemo combo.  Of these, only Keytruda is an immunotherapy.

Have you looked through clinical trial options?  What are your mother’s doctors recommending?

Regards, Mary