Bgulmus

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  • in reply to: anti PD1 treatment #97750
    Bgulmus
    Participant

    Lily

    High dose vitamin C injection has given very good results against Kras mutation. most pancreatic cancer has KRAS mutation. there is a trial going on vit C-pancreatic cancer (KRAS)  theraphy. pls check out.

    ”There is a trial going on at Weil Cornell using vitamin C. I think it is for people with certain KRAS mutations and maybe also for people with BRAF mutations. Unfortunately, it is for pancreatic cancer only.”

    Bgulmus
    Participant

    Thank you Mary, very helpful.

    Bgulmus
    Participant

    Hello, so is this a immunotheraphy drug ? I m still reading but couldnt have an idea?!

    in reply to: anti PD1 treatment #97676
    Bgulmus
    Participant

    Thank you Mary

    What I ve understood from foundation one results and immuno drugs , in principle

    they are checking seperately 3 main things:

    1- gene mutations and its quantitty so that to understand if the reason/main cause of the cancer is gene mutations?

    2- capability of repairements of DNA (MS)

    3- if tumor tissue has PLD1 protein (which stops immune system to recognize if it is a tumor)

    in my understanding researchers mostly have developed drugs for patients whose tumor has PLD protein. Thats why pld1 negative people (like my mom) are not a good candidate for approved drugs. So I have to search for drugs/trials working on MS stabled and gene mutated patients ? am I correct?

    • This reply was modified 3 years, 8 months ago by Bgulmus.
    in reply to: anti PD1 treatment #97675
    Bgulmus
    Participant

    my mom is 68.

    barish - mutations

    PD-L1 Tumor proportion score TPS % 0

    KRAS amplification-equivocal, G12R

    CDKN2A/B loss

    KMT2C (MLL3) deletion exons 4-40

    MS stable

    TMB-Low; 3 muts/MB

    I attached other gene mutations.

    in reply to: anti PD1 treatment #97674
    Bgulmus
    Participant

    Lili, No stop! it was a trial! keep looking for another trial. as long as your father is emotionallly and physically eligible, you have to keep searching. We all know still there is no certain cure for the illness. the goal here is to make them live in good shape with the illness with medicines and treatments! please please have a little break and keep searching.

    in reply to: anti PD1 treatment #97662
    Bgulmus
    Participant

    Hello again Lili, I need help please. we ve received Foundation one results a few days ago. gene based treatment  is very new in here and cant make sure if our  oncologists can make up-to date comments! I ve talked to 2 oncologists and both of them are saying, “nothing to do with immunotheraphy with your results”.  We ve got :

    Tumor prop score: % 0

    Tumor Mutational burden- Low, 3muts/ Mb

    MS – stable

    Kras

    CDKN2A/B

    KMT2C.

    can you comment based on your experience? can you direct me? what to search  in clinicaltrials.org?

    all the best.

    • This reply was modified 3 years, 8 months ago by Bgulmus.
    in reply to: hope? #97619
    Bgulmus
    Participant

    Hello Lily

    great to hear from you. Thank you very much. I have already started to check your chemo helping suggestions. Since her first folfox, she s lost 3-4 kilos, sleeping 16 hours a day, no appetite at all for the past 10 days…  I hope your ideas will help.

    Thank you for the warning. we had ordered PD-1/ PD-L1 too at the beginning. another good friend reminded to add them.

    wishing you all the best.

    Barish

    in reply to: hope? #97582
    Bgulmus
    Participant

    Hello Mary

    I m glad to find the foundation community. I m thoroughly reading everything on the site. And will share our experiment in order to assist the community.

    Yes, we also had a PET scan, Toraks BT, MR. there is a tumor on the (?new) tissue which was replaced the resected lymp node area. And also there are a few dark areas in/on the liver which are considered metastase tumoric pieces.No far metastase observed.

    on march 12 she had her left liver, gall bladder and lymph node (around the duct) resected. (attched is the current PET)

    regards, Barish.

     

     

     

     

     

     

Viewing 9 posts - 1 through 9 (of 9 total)