foodie
Forum Replies Created
-
Posts
-
Suzanne- I can’t tell you how very happy I am, elated to hear your fantastic news. You have been fighting so hard, your news is the best and I know this will be a wonderful holiday full of hope and the good things that will come your way. Kim thinks the world of you, I can’t wait to talk to her about your awesome news. she is at emory and just head her RFA today ( it went great I am told, better then expected), so good news all around for you two beatiful Georgia gals…. Love to you and your family, now have some fun.
Thank you all for your prayers and positive energy. And thanks to God.
My sister came home today. Her recovery and spirit have been nothing short of a miracle. she will have challenges ahead, but if sheis able to keep her spirit up the way she has, she will overcome this without looking back. she will have staples removed in another 12 days, and she has has some expected pain, but she does not look like someone who just had such a major operation. our thoughts and prayers are with all of you too, and please continue to lift Kim in prayer.thank you so much everyone, our prayers have been answered. she just finished surgery. her entire right lobe was taken, gallbladder and a spot on left ablated, they saw no spread anywhere else and she is in recovery. I am so grateful to this incredible surgeon, of course god and all of your prayers. will keep you updated. a specaial thanks to suzanne who has been guiding us and helping us through this process with her own experience , she is an angel… thank you, thank you thank you
Suzanne-
I can’t thank you enough. I know this will help in more ways than one. You have had such a battle, yet you are so giving of yourself and your time. I know my sister will appreciate the information and I am so happy you have some great local resources. I have forwarded her your info , and really can’t express how greateful I am that you have taken the time to share in such detail.
Many blessings to you
PeaceSuzette
falkol202,
I am so sorry about your illness, it is a horrible disease and my heart and prayers are with you. I live in Connecticut, and my sister who is the one with stage 4 Cholio ( she livers in georgia)went to may 2 weeks ago, we met with An oncologist and then Doctor Lombardo at mayo. In my sisters case, her cancer had grown since being diagnosed weeks earlier and they were not sure that at this time there would be enough healthy liver to leave so they want her to go through a few rounds of chemo first. They did say that if they thought whe was a candidate, they would first take a look laproscopically before opening to make sure there was no spread, that included the lymph nodes. They said they would rule our operating if the nodes were involved. I have read differently though on other sites with other doctors. UPMC has an agressive program, new york presb, and barnes jewish hospital. My view is you gotta keep hope, keep looking, it only takes one doctor to say yes.
I am not sure if this is of any help or interest, but there is a clinical trial that just started at Yale- here is the info…
found this clinical trial and I thought it might be of interest, happy to look further if it looks like it might be useful .
http://www.novogen.com/news/news0501.cfm?mainsection=05&subsection=01&newsid=309Came across this and thought some might be interested
Jan 08, 2009 (M2 EQUITYBITES via COMTEX) — MSHL | Quote | Chart | News | PowerRating — Marshall Edwards Inc (NasdaqGM:MSHL), a specialist oncology company focused on the clinical development of novel anti-cancer therapeutics, said on 7 January that the company has received Investigative New Drug (IND) approval from the United States Food and Drug Administration (FDA) to undertake clinical studies with triphendiol as a chemosensitising agent in combination with gemcitabine.
The company stated that the approval will allow a Phase Ib study of triphendiol in combination with gemcitabine in patients with unresectable, locally advanced or metastatic pancreatic and bile duct cancers. A Triphendiol (NV-196) is an investigational drug, currently being developed as an orally-delivered chemosensitising agent, intended for use in conjunction with standard chemotoxic anti-cancer drugs for the treatment of late stage pancreatic cancer, cholangiocarcinoma and melanoma.
Dr. Wasif Saif
Yale University School of Medicine
Section of Medical Oncology
333 Cedar Street, FMP 116
New Haven, CT 06520
United States of America
Bus: +1 (203) 737-1569
Bus Fax: +1 (203) 737-2617Triphendiol Safety Data Clears the Way for Compound to Be Studied Further in the Treatment of Pancreatic Cancer
AACR Abstract # 5101; Poster Presentation, 4/22, 8 am – NoonNEW CANAAN, CT – Marshall Edwards, Inc. (NASDAQ: MSHL). An abstract titled “Pre-clinical Toxicology of Triphendiol (NV-196)” will be presented at the Annual Meeting of the American Association for Cancer Research, April 18-22 in Denver, showing that triphendiol has an acceptable toxicity profile in animals. To view the abstract online, click here.
Triphendiol was granted orphan drug status by the U.S. Food and Drug Administration for pancreatic cancer and cholangiocarcinoma in January 2008, and for treatment of stage IIb-IV malignant melanoma in February 2008. In January of 2009, triphendiol was granted an Investigative New Drug (IND) approval by the United States Food and Drug Administration to undertake clinical studies with triphendiol as a chemosensitizing agent in combination with gemcitabine.
The abstract, to be presented by Dr. Wasif Saif, Associate Professor and Co-Director, Yale Cancer Center Gastrointestinal Cancers Program, Yale University School of Medicine, summarizes data from a number of preclinical studies performed in order to obtain data to support the IND filing. In in vitro studies, triphendiol was non-mutagenic in the bacterial reverse mutation assay (Ames test) and non-clastogenic in the mouse erythrocyte micronucleus assay. Studies in animals indicated not only acceptable pharmacokinetics, but also no accumulation of triphendiol when administered to animals in repeated doses. Also there were no toxicologically important changes in clinical signs, body weights, hematology, coagulation time, serum chemistry, urinalysis, gross observations, organ weights or histologic findings for any study animal. There were no significant changes to heart rate and the Q-T segment interval indicating a lack of cardiovascular toxicity.Best of luck to you
Hi Suzanne,
Unfortunately the situations do sound similar, I am so happy you were able to get your surgery, knowing this has really given me a hopeful outlook. Right now, my sister is in her 2 nd week of chemo ( xeloda and gem). She said she is scheduled for a new scan on the first as her enzymes are still climbing. As it turns out, she had been given thge name of Dr. Kooby and also Dr. Staley. She was actually scheduled for an emory surgery review appointment last monday, but cancelled after a dissappointing outcome at mayo beying told that her cancer had spread over the first month of diagnosis ( she had not had any treatment , it took a while to figure out is was cholangio) so surgery was out for now unless the tumor reacted to the chemo, and knowing that she only had one day to recover prior to the start of chemo. I think her hope is to go back to emory once she has had some chemo to stabalize her situation .
Would you mind giving me a little history of what you have done ( and in what order?) Is there anything besides chemo that you had done that helped?
It has been hard not knowing anyone with this. My sister also asked if you wouldn’t mind sharing your email with her. Her name is Kim and she lives in Macon. I am sorry to ask, it is such a gift you are giving to help someone else. I so appreciate it and will keep you in my prayers.
best,
SuzetteHi Terri,
I am so very happy to hear about your sister and the outcome of her surgery, it is really providing me with some hope too. My sister was diagnosed with intrahepatic cholangio about 4 weeks ago, we knew about two weeks before that she had cancer in her liver but they were not sure where the primary was at that point. We went to mayo 2 weeks ago in hopes that surgery would be a real possibilty. Unfortunately in the 3 1/2 weeks from the first scan the cancer had spread about 20% more. The majority of the right is covered and there is a definate spot on the left . They wanted her to do 2 rounds of chemo and then see if it shrank at all. they wanted at least 30% left . She left feeling devistated as you can imagine. she is only 41. I know in my heart that surgery is the way to go, we just need to convince someone. She has been basically asymptomatic ( with the exception of high calcium) she is young, beautiful, strong and a great m om to two awesome kids that need her.
I was hoping you could share with me your sisters doctor in atlanta, and also if the surgery was done at emory???
thank you so much and god bless you and your sister.
