jpsenka

Hi Everyone,

I’ve looked into fever therapy a bit. I believe it has its roots in a therapy referred to as Cooley’s Toxin. Cooley was a physician who noticed that high, repeated fevers caused tumor regression. It is still a matter of debate whether Cooley’s Toxin works via immune activation, or by “cooking” the tumors. It is known that tumors often don’t have the same level of vascularization as normal tissue, and this prevents them from cooling themselves easily. One interesting aspect of using hyperthermia with blood-based treatments like chemo is that the heat can cause blood vessels to dilate and deliver more blood, and hence more therapy to the tumor. Tumors can defend themselves from excessive heat by producing something called Heat-Shock Protein 27. The level of this protein can be measured in a biopsy sample, but this is frequently done in the US. Hope this helps!