pcl1029
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Hi,
You are welcome my friends, Lainy and Gavin.In a conversation with the poster presenter of the “FINAL analysis of the BINGO trial “( GEMOX+ cetuximab ,the study that claimed > 60% in PFS) , a stunning surprise to me at least is that , he indicated that the final result is a ” NO GO” in his own words. That means GEMOX+cetuximab is no better than GEMOX alone.( actually IT is about a month longer in PFS compared to GEMOX alone)
He told me at least for now, he will not spend another five millions dollars or euro(the study was done in France.) on it again.I will report more later .
God bless.Hi,
Also I have the chance to ask one of the clinical person at the SIR-Spheres booth at ASCO today with regard to your question about low grade fever for four months; he said, if the ALK PHOS is below 800-900, then the low grade fever is NOT related to theY 90 procedure. However, if it is above 900 and did not come down later, let say, a month or so. Then it may be y 90 radiation related but then again, this is off the label findings and may not be of definitive for such findings.
God bless.Hi,
I agree with the triphasic CT liver with that 15 min. delay to have a better picture.
I also think your oncologist does not want to over treat your mom’s thyroid may be a good idea. Most of the chemo and targeted agents do carry cardiotoxity apart from other side effects,and the toxicities are accumulative . I went to a session in ASCO talking about cardio toxicity , the monoclonal antibodies like Avastin or Erbutix ,because they are angiogenesis inhibitors, they may therefore affect the NORMAL repairing of the heart and cardiovascular system. In that sense it may apply to other targeted agents like Naxavar and of course the alkylating agents as well.And I have just learned that age ,medical history like diabetes,hypertension,etc may be a factor in dosing adjustment and choices of chemo agents as well as targeted agents.” So less may be better than more” may make sense.
God bless.Hi, everyone ,
today is the second day at the convention; to my surprise ,there are still no valid biomarker or test that either for prognosis or for predictive use for treatment.(ie;they are no NEGATIVE markers available to validate test or drug performances)and in some case ,poor performing tests produced differences and it cannot be fixed by retesting.
Another thing I found out is that ,in some cases,even they find out the targeted agent is useful for the tumor at first treatment; resistance occur later because the tumor develops newer pathway and therefore the targeted drug that was used is no longer works.
There are also ample evidences to indicate that the microenviroment around the tumor is of utmost importance to the survival of the tumor.The blood vessels,the lymphatic vessels;the matrix that between the two vessels systems and the antibodies that located nearby will all contribute to the effectiveness of the chemo and targeted agent treatment . In short,normalizing tumor microenviroment to treat the canner;using blood pressure medication(Losartin and others ARBs) to lower the interstitial fluid pressure for both the blood vessels and the lymphatic vessels;increase higher oxygenation to the affected areas will provide remarkable improvement in treatment efficacy including chemotherapy,radiation and immune therapy.
Dr. Rakesh Jain,the speaker from MGH who received the 2012 Science of Oncology award,also indicated that” in the next 5 years,there will be major developments in personalizing cancer therapy,using not only the genetic signature but also the microenviromental signature of cancer.” His team is searching for better normalizing drugs and seeking imaging , and /or tissue biomarkers that may help in the personalization of therapy.
His team included 200 doctoral and postdoctoral fellow across multiple disciplines and have produced 550 publications.
God bless.Hi,Lainy ,
Good for you,
BTW,I am leaving for the convention now.
Sometimes ,I really would like to have a convention of just our own,the members , patients and care givers, all together,to sing songs, to do a little out of the norm crazy things to enjoy life in a different way than the norm.
May be we all take a cruise ,go the Europe,pick up our friends there, and have a pow wow gathering.
God bless.Hi, Janet,
Your husband set a good example for all of us,especially patient to follow.I will try to do the same if my wife will agree when the time is come.
You are a good Christian to show us the faith of you and the trust you have on Him. You are an example of courage for us,you said you will not go away and will be back on the message board to contribute what you can to help others even at the time of sorrow . My friend, your devotion is worth a ton of love. And an example for all of us to follow.
I salute you.
May the Love of our Jesus Christ, the Grace of God and the Fellowship of the Holy Spirit be with you and guide you all the way.
God bless.Hi,
I believe do not eat Sushi is an absolutely good idea .if you have to,which is no guarantee, go to the expensive and top restaurant . I will say, especial to the young generation, to avoid eating Sushi, and “hot pot “from Chinese ,Koren,Thai ,Vietnam and Japan restaurant in the States and Canada, and buffet outlets alike .
Most of them use frozen fish and no way you know where they came from.One time I shopped for frozen fish ,they are the “product of Thailand “.and some other just marked as “distributed by L.A. From California .” I think that means the fish is not from here or Canada. By the same token,people in Europe should do the same and make aware of the origin of the product. I am not against buying those product, I just want people know about the risk.
I learn long time ago,do not eat fish raw or semi raw(hot pot style) (ie:unless the water inside the hot pot is BOILING CONTINUOUSLYand you let the piece of fish boiled until it completely turn white for a while, then use the spoon to pick the fish up, the reason is if you just use the chopstick alone ,the part of the piece of the fish that the chopstick make contact all the time may not be cooked well even it looks white on the outside) .In general, fish must be well cooked .
Most rivers and nearbye ocean in the newly developed countries are polluted in the far east by our western standard.
What I am trying to say is about PREVENTION of this disease,shop wisely, advise yourself and others ,especially the trendy young generation to avoid what can happen down the road.
God bless.Hi,
Please write to me after 6/5. If you are interested in herbal medicine.but for now Sloan-Kettering web site is a good place to start to learn as well as our experiment forum on complimently and alternative (CAM) section.
God bless and may Him guide you to the correct path to praise Him.
God bless.Hi,
Board spectrum IVABX like cefepime,levequin can be useful for gram pos and gram neg bacteria E coli.
Gentamicin and tobramycin are other inexpensive IVABX to cover gram negative bacteria mostly.
When discharged oral abx like Levaquin,Cipro and ceftin( if not allergic to penicillin) can be of use,
God bless.Hi,
Here is the link.
God bless.http://radiology.rsna.org/content/early/2012/05/15/radiol.12112142.sho
Hi,
Hi,
To answer your question:
1. As long as the doctors see the need to have stents for your husband,they will do so to help the bile flow smoothly;so do not worry about how many stents they do or will do. comfort for your husband is the key here.
2.IV antibiotics (IVABX) are powerful and your husband has three;Augumentin is only by mouth and is not as strong as Timentin thru IV alone. that is why the IVABX brought the the temperature down but may not be enough by Augumentin alone; ask the doctor to check on this ;may be he can add another BOARD spectrum antibiotics to help to bring down the tmep.
3.with regard to methadone;since it has been 3-4 days now ;and if the hospital the situation from the start as you indicated; the drug side effect should be gone by now and you should not be worry. Normally there is a safety margin built in for drugs by the drug company . There are narrow safety margins for some drugs like digoxin and coumadin . But there are boarder margins for oral antibiotics and other medicines like some pain killers. But of course,5 times overdose is not a good thing,but since it happened in the hospital and caught early;things should be improved.4. with board spectrum antibiotics like Levaquin taking for 10-14 days,there is much less chance for fever to last.Blood culture are not always reliable but the symptoms does. i am sure the doctors knows what to do. so please don’t worry.
5. PCT or ERCP procedures are determined by the availability and easy assess of the locations;you should leave this for the doctors to worry and not yourself;you have a lot on your shoulder already.
6. dark urine may be related to the bilirubin level(bile flow);ask the doctor for an answer.(ie: make the doctor aware of your concern about the urine and they will act accordingly.);it may also related to hydration or other reasons. But then again ,Phil, this is why we pay the medical system(either thru tax or insurance) so much and now is the time for them to help you out.
7.Augumentin normally will not cause fever;but in extremely rare cases(very remote chance) it may caurse “drug fever”.
Augumentin is not the drug of choice for patients who have liver problems;If I remembered correctly, several patients on this message board who were on Augumentin had problem with it. you can google the name of the drug and side effect and you may find the answer.
God bless.hi,
I agree with Marion(100%) that it is time for hospital to get the appropriate medical treatment that she deserved.
One of the most important things in caregivers responsibility is to know when to seek professional help;when to use the knowledge you have to better the care that the patient received .
In your case, Haldol,Xanax, etc are good drugs for patients if the dose is right and titrated to the best optimal level to control symptoms. and this can only be done by medical professional in the hospital setting at this time for your sister’s current medical condition. They either can give the patient the same medicine(ie:by iv route) to increase the comfort for the patient.;or use other medications to help the patients and provide the comfort that your sister needs.
I am not a doctor, but in this case ,if I am her brother,for the skae of the patient; IT IS TIME to bring for hospital visit for proper medical care instead of helping her by her caregivers unless you are a doctor with the practical knowledge of this cancer.
God bless.Hi,
I also brought up your problem about no uptake for the FDG on your PET/CT ;my radiologist friend said it could happen and just take another one to see what happen.He said false negative for PET is not uncommon,on the other hand ,the same (false positive) is not uncommon can be applied to PET scan too.
God bless.
