Posts by Kelly Butler

Fibroblast growth factor receptor 2 (FGFR2) is among cholangiocarcinoma’s most frequently altered genes.

The first line of treatment for unresectable cholangiocarcinoma is gemcitabine plus cisplatin…

In diagnosing cholangiocarcinoma, it is essential to distinguish it from other conditions that can have similar symptoms or presentation…

A recent study explored the therapeutic regulation of PD-1’s alternative splicing for potential anti-tumor effects in cancer therapy research.

Tiliacora triandra is a plant native to Southeast Asia used for cooking and traditional herbal medicine.

In addition to aiding in digestion, bile acids may contribute to the formation and progression of gastrointestinal cancers.

External radiation has been used to treat cancer for many years, but recent technological advances have led to a new form of radiation from implanted iodine 125 (125I) “seeds.” This new approach is advantageous since it allows high doses of targeted radiation with minimal damage to surrounding tissues while being more convenient for patients than…

About 98% of the human genome is non-coding, meaning it does not contain the genetic code to make proteins. However, these non-coding regions are not “junk DNA.” Instead, they contain important regulatory elements that can affect gene expression, protein levels, and protein activity. One type of non-coding element is circular RNAs, and a recent study…

Radiomics Models May Help Identify Candidates for Surgery Most cholangiocarcinoma tumors are unfortunately detected at advanced stages, but surgical resection is sometimes possible for earlier-stage cancers. To better identify patients who may benefit from surgery, researchers are working to develop ways to predict postoperative disease recurrence. A recent study thus identified variables associated with post-surgical…

LCK Inhibitor: A Novel Potential Therapy for Cholangiocarcinoma A variety of signaling pathways can become overactive in cancer to promote cell growth. One of these pathways is known as the Hippo signaling pathway, which involves the activation of “yes-associated protein” (YAP). YAP is regulated by another protein called LCK, which can turn on YAP through…

Apigenin-Conjugated Gold Nanoparticles: A Potential New Treatment for Cholangiocarcinoma