Trials, Targeted Agents Often Lead to Financial Toxicity From CCA

Clinical trials and targeted agents do not appear to affect health care–related quality of life, however.

July 27, 2022 -- People with cholangiocarcinoma (CCA) who enroll in a clinical trial or receive targeted therapy suffer a significant financial burden, but their health care–related quality of life (QOL) is unaffected, according to a new report published in Journal of Surgical Oncology.

The report highlights the burdens faced by people with CCA and the ways in which those burdens extend beyond the physical symptoms of the disease.

The study authors note that a diagnosis of CCA brings with it a dim prognosis. Most patients will not discover their cancers early enough to undergo surgical resection, even though surgery is the only treatment considered curative. Even when resection occurs, recurrence rates are high.

Patients who undergo resection typically are given adjuvant capecitabine, while cisplatin plus gemcitabine is the first-line option in advanced cases, the authors noted.

The lack of curative options leads many patients to seek out clinical trials or targeted therapies. The authors noted that the FOLFIRINOX (folinic acid, fluorouracil, irinotecan hydrochloride, oxaliplatin) and FOLFOX (folinic acid, fluorouracil, and oxaliplatin) chemotherapy regimens have shown promise in clinical trials of patients with advanced biliary cancers, and targeted molecular agents have also raised hopes.

“The application of these therapies continues to evolve and expand into the first-line setting,” the authors noted. “However, our understanding of the long-term patient-specific outcomes beyond toxicity and disease survival is limited.”

To read the article in its entirety by Jared Kaltwasser for AJMC, click here.

Reference

Keilson JM, Lindsey S, Bachini M, et al. Patient reported outcomes: financial toxicity is a barrier to clinical trials and personalized therapy in cholangiocarcinoma. J Surg Oncol. Published online July 15, 2022. doi:10.1002/jso.27012

Melinda Bachini

Melinda Bachini

Stacie Lindsey

Stacie Lindsey

Sources of Financial Assistance

The Cholangiocarcinoma Foundation is aware of the financial strains associated with cancer. To help, this listing of resources has been provided for you to seek assistance.

Federal & State Programs

There are programs that provide entitlements for low-income households, older adults, and the disabled. Each entitlement has eligibility requirements. Check with your state government for programs that can help with healthcare-related needs.

U.S. Department of Health & Human Services

Information on public assistance and food stamps.

U.S. Administration on Aging

Benefits for older adults. Eldercare Locator finds resources in your community.

800-677-1116

Centers for Medicare & Medicaid Services

800-633-4227

Social Security Administration

800-772-1213

Pharmaceutical Patient Assistance

Programs and services differ among drug manufacturers but may include:

  • Help with insurance reimbursement
  • Referrals to co-pay relief programs
  • Help with the application process
  • Discounted or free medications for patients who do not qualify for other assistance

To see if the drug company that makes your medication has a patient assistance program, check its website. You can also ask your doctor or use the Medicine Assistance Tool. Needy Meds also helps with costs.

Medicine Assistance Tool

Needy Meds

800-503-6897

Co-Pay Relief

Several nonprofit organizations provide help for expenses such as drug co-payments, deductibles, and other medical costs. Contact each organization to learn more.

CancerCare® Co-Payment Assistance Foundation

866-55-COPAY (26729)

Good Days

877-968-7233

HealthWell Foundation

800-675-8416

National Organization for Rare Disorders (NORD)

800-999-6673 203-744-0100

Patient Access Network Foundation

866-316-7263

Patient Advocate Foundation Co-Pay Relief Program

866-512-3861

General Organizations

United Way

Check to see if there is a 211 information and referral service (www.211.org) in your area.

Special thanks to CancerCare® for sharing this information.