This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.

Study Name
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
ClinicalTrials.gov Identifier (if applicable)
NCT03785249
Clinical Trial Category (check all that apply)
  • Beyond First Line Therapy
  • Targeted Therapy
Study Center
Institution Name
Multiple Sites (See Below)
State
– Please Select –
Country
United States
List additional Institutions (include address, phone number, and website)
Please visit https://clinicaltrials.gov/ct2/show/NCT03785249 for the latest information

University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
United States, Alaska
Alaska Oncology and Hematology Recruiting
Anchorage, Alaska, United States, 99508
United States, Arizona
Mayo Clinic in Arizona Recruiting
Phoenix, Arizona, United States, 85054
Arizona Oncology Associates Recruiting
Tucson, Arizona, United States, 85704
United States, California
Kaiser Permanente-Bellflower Medical Offices Recruiting
Bellflower, California, United States, 90706
Beverly Hills Cancer Center Recruiting
Beverly Hills, California, United States, 90211
City of Hope Recruiting
Duarte, California, United States, 91010
St. Joseph Heritage Healthcare Recruiting
Fullerton, California, United States, 92835
University of California San Diego Moores Cancer Center Recruiting
La Jolla, California, United States, 92093
Hoag Memorial Hospital Presbyterian Recruiting
Newport Beach, California, United States, 92663
University of California, Irvine Recruiting
Orange, California, United States, 92868
California Cancer Associates for Research and Excellence Recruiting
San Diego, California, United States, 92111
Ridley – Tree Cancer Center – Santa Barbara Recruiting
Santa Barbara, California, United States, 93105
Kaiser Permanente Recruiting
Vallejo, California, United States, 94589
United States, Colorado
Rocky Mountain Cancer Centers Recruiting
Aurora, Colorado, United States, 80012
University of Colorado Hospital Recruiting
Aurora, Colorado, United States, 80045
St. Mary’s Hospital & Regional Medical Center – Research Recruiting
Grand Junction, Colorado, United States, 81501
United States, Connecticut
Yale Cancer Center Recruiting
New Haven, Connecticut, United States, 06511
United States, Delaware
Medical Oncology Hematology Consultants Recruiting
Newark, Delaware, United States, 19713
United States, Florida
Mayo Clinic in Florida Recruiting
Jacksonville, Florida, United States, 32224
Mount Sinai Comprehensive Cancer Center Recruiting
Miami Beach, Florida, United States, 33140
Miami Cancer Institute Baptist Health Recruiting
Miami, Florida, United States, 33176
Mid Florida Hematology and Oncology Center Recruiting
Orange City, Florida, United States, 37263
Woodlands Medical Specialists Recruiting
Pensacola, Florida, United States, 32503
BRCR Medical Center Recruiting
Plantation, Florida, United States, 33322
United States, Georgia
Northwest Georgia Oncology Centers, PC Recruiting
Marietta, Georgia, United States, 30060
United States, Illinois
Illinois Cancer Specialists – Niles Recruiting
Niles, Illinois, United States, 60714
United States, Iowa
University of Iowa Hospital & Clinics Recruiting
Iowa City, Iowa, United States, 52242
United States, Kansas
University of Kansas Medical Center Recruiting
Westwood, Kansas, United States, 66205
United States, Kentucky
University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536
United States, Maine
Main Health Cancer Center Biddeford Recruiting
Biddeford, Maine, United States, 04005
United States, Maryland
Maryland Oncology Hematology-Columbia Recruiting
Columbia, Maryland, United States, 21044
United States, Massachusetts
Massachusetts General Hospital Recruiting
Boston, Massachusetts, United States, 02114
Dana Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02215
United States, Michigan
Henry Ford Medical Center Recruiting
Detroit, Michigan, United States, 48377
United States, Minnesota
Minnesota Oncology Recruiting
Minneapolis, Minnesota, United States, 55102
University of Minnesota Recruiting
Minneapolis, Minnesota, United States, 55454
Mayo Clinic in Minnesota Recruiting
Rochester, Minnesota, United States, 55905
Metro-Minnesota Community Oncology Research Consortium Recruiting
Saint Louis Park, Minnesota, United States, 55416
United States, Missouri
Goldschmidt Cancer Center- Central Region Medical Center Recruiting
Jefferson City, Missouri, United States, 65109
United States, Montana
Frontier Cancer Center Recruiting
Billings, Montana, United States, 59102
United States, Nebraska
Nebraska Cancer Specialists Recruiting
Omaha, Nebraska, United States, 68130
University of Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
United States, Nevada
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89169
United States, New York
Roswell Park Recruiting
Buffalo, New York, United States, 14263
Perlmutter Cancer Center Recruiting
New York, New York, United States, 10016
Memorial Sloan Kettering Cancer Center Recruiting
New York, New York, United States, 10065
United States, North Carolina
University of North Carolina Recruiting
Chapel Hill, North Carolina, United States, 27514
FirstHealth Outpatient Cancer Center Recruiting
Pinehurst, North Carolina, United States, 28374
United States, Ohio
University of Cincinnati Health Barrett Cancer Center Recruiting
Cincinnati, Ohio, United States, 45219
Cleveland Clinic Recruiting
Cleveland, Ohio, United States, 44195
OSU Medical Center Recruiting
Columbus, Ohio, United States, 43210
Kettering Cancer Center Recruiting
Kettering, Ohio, United States, 45429
United States, Oregon
Willamette Valley Cancer Institute and Research Center – Eugene Recruiting
Eugene, Oregon, United States, 97401
United States, Pennsylvania
Lehigh Valley Heath Recruiting
Allentown, Pennsylvania, United States, 18103
Penn State Health Milton S. Hershey Medical Center Recruiting
Hershey, Pennsylvania, United States, 17033
United States, South Carolina
Charleston Oncology P.A. Recruiting
Charleston, South Carolina, United States, 29414
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
United States, Tennessee
Tennessee Oncology/The Sarah Cannon Research Institute Recruiting
Nashville, Tennessee, United States, 37203
United States, Texas
Texas Oncology-Arlington Recruiting
Arlington, Texas, United States, 76014
USOR – Texas Oncology – Austin Central Recruiting
Austin, Texas, United States, 78731
Mary Crowley Cancer Research Recruiting
Dallas, Texas, United States, 75231
Texas Oncology at Presbyterian Dallas Recruiting
Dallas, Texas, United States, 75231
USOR Texas Oncology Baylor Charles A. Sammons Cancer Center Recruiting
Dallas, Texas, United States, 75246
Texas Oncology Recruiting
Fort Worth, Texas, United States, 76104
The University of Texas MD Anderson Cancer Center Recruiting
Houston, Texas, United States, 77030
South Texas Accelerated Research Therapeutics Recruiting
San Antonio, Texas, United States, 78229
Texas Oncology Recruiting
Sugar Land, Texas, United States, 77479
Texas Oncology Recruiting
Tyler, Texas, United States, 75702
United States, Virginia
Virginia Cancer Specialists Recruiting
Fairfax, Virginia, United States, 22031
Virginia Oncology Associates-Newport News Recruiting
Newport News, Virginia, United States, 23606
United States, Washington
Seattle Cancer Care Alliance Recruiting
Seattle, Washington, United States, 98109
USOR – Compass Oncology – Vancouver Recruiting
Vancouver, Washington, United States, 98684
United States, Wisconsin
University of Wisconsin Carbone Cancer Center Recruiting
Madison, Wisconsin, United States, 53792
Puerto Rico
PanOncology Trials Recruiting
San Juan, Puerto Rico, 00935

Study Contacts
Principal Investigator
Multiple Sites
P.I. Phone
(844) 893-5530
P.I. Email
miratistudylocator@emergingmed.com
List additional Principal Investigators (include phone number and email)
Please visit https://clinicaltrials.gov/ct2/show/NCT03785249 for the latest information
Study Coordinator
Mirati Therapeutics Study Locator Services
Study Coordinator Phone
(844) 893-5530
Study Coordinator Email
miratistudylocator@emergingmed.com
OVERVIEW – in layman’s terms (150 words max)
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
Enrollment
565 participants
Study Start Date
01/15/2019
Estimated Completion Date
12/31/2022
Purpose of the Study – in Layman’s Terms (use the “+” to add more list items)
  • This study will evaluate the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 (adagrasib) is an orally-available small molecule inhibitor of KRAS G12C.
Inclusion Criteria – Patients Must:
  • Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation
  • Unresectable or metastatic disease
  • Standard treatment is not available or patient declines
  • Adequate organ function
Exclusion Criteria – Patients Must NOT:
  • History of intestinal disease or major gastric surgery or inability to swallow oral medications
  • Other active cancer
REQUIRED TESTS PRIOR TO BEGINNING STUDY TREATMENT – in layman’s terms
  • KRASG12C mutation, which will be identified by the healthcare team