A Phase II Multicenter, Single Arm Study of Oral BGJ398 in Adult Patients With Advanced or Metastatic Cholangiocarcinoma With FGFR2 Gene Fusions or Other FGFR Genetic Alterations Who Failed or Are Intolerant to Platinum-based Chemotherapy

Study Name   A Phase II Multicenter, Single Arm Study of Oral BGJ398 in Adult Patients With Advanced or Metastatic Cholangiocarcinoma With FGFR2 Gene Fusions or Other FGFR Genetic Alterations Who Failed or Are Intolerant to Platinum-based Chemotherapy ClinicalTrials.gov Identifier (if applicable)   NCT02150967 Study Center Institution Name   Novartis Pharmaceuticals Institution Address   One Health Plaza City   East Hanover State   New Jersey Zip Code   07936 Phone   (888) 669-6682 Website   https://www.novartis.com/ Study Contacts Principal Investigator   TBD P.I. Phone   (888) 669-6682 P.I. Email   novartis.email@novartis.com List additional Principal Investigators (include phone number and email)   Please refer to the Clinical Trials.gov listing and contact Novartis at 1-888-669-6682 for a research center near you Study Coordinator   TBD Study Coordinator Phone   (888) 669-6682 Study Coordinator Email   novartis.email@novartis.com List additional Study Coordinators (include phone number and email)   Please refer to the Clinical Trials.gov listing and contact Novartis...

2nd Annual Fundraiser in Honor of Kelly Gratz

July 2017 was the second annual fundraiser for the Cholangiocarcinoma Foundation in honor of Kelly Gratz.  Kelly was diagnosed in February 2016 with stage 4 Cholangiocarcinoma. His children decided to host a fundraiser to rally as much emotional support for him through this battle and also to be able to raise money for the foundation and research. It was successful last year so they did it again this year. The fundraisers included a softball and volleyball tournament, along with 20+ raffle baskets, silent auction items, and a 50/50 raffle. Also in gathering donations, the facility used to host the fundraiser donated a percentage of all food and drink sales to the foundation.  Lastly, a local horse show that his daughter participated in donated a portion of their money from the riders’ entry fees to the foundation as well. This year, we were able to raise $13,000 for the Cholangiocarcinoma Foundation – double what we were able to donate in...

Meet Professor Juan W. Valle’s Research Team

Meet Professor Juan W. Valle's Research Team Principal Investigator: Juan W Valle Professor in Medical Oncology; Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), Manchester. Consultant in Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester. Location: The Christie NHS Foundation Trust (Manchester, United Kingdom) Website: http://www.christie.nhs.uk/ Established: 2000 Researchers: 4 Senior Staff in medical oncology; 2 PhD students; 2 research fellows; 4 research nurses, 1 nurse clinician, 1 clinical nurse specialist, a team of clinical trial coordinators, a project manager, a dietitian and various students Goal: Professor Valle’s team is focused on clinical and translational research in cholangiocarcinoma and other Hepato-Pancreato-Biliary tumours. They aim to understand clinical characteristics of patients with cholangiocarcinoma and develop new options of treatment. Professor Valle’s team has successfully changed practice in cholangiocarcinoma by participating in national and international clinical trials, such as the ABC-02 study...

Step inside The Kwong Lab

Step inside The Kwong Lab Principal Investigator: Lawrence Kwong, PhD, Assistant Professor of Translational Molecular Pathology Location: University of Texas MD Anderson Cancer Center Website: https://www.mdanderson.org/research/departments-labs-institutes/labs/kwong-laboratory.html Established: 2015 Researchers: 4 postdoctoral fellows, technicians, and students; 2 visiting students Message to Patients Dr. Kwong would like to stress that patients are the number one focus at MD Anderson. Therefore, as a researcher, it is vitally important that our laboratory maintain human contact with patients through communications, attending conferences where patients and survivors are present, and keeping in close contact with doctors who specialize in cholangiocarcinoma. Goal: The laboratory is establishing new cholangiocarcinoma mouse models and cell lines to test drug combinations and understand how DNA is affected by this cancer. Greatest Achievement: Dr. Kwong considers collaborating with cholangiocarcinoma- specializing doctors including oncologists, pathologists, and radiologists at MD Anderson and elsewhere as a major step towards linking our findings in the...

Take a step into the Bardeesy Lab

Location Massachusetts General Hospital (MGH) Website http://www.bardeesylab.com Established 2005 Principal Investigator Nabeel Bardeesy, PhD Associate Professor of Medicine at Harvard Medical School Faculty at the MGH Center for Cancer Research Affiliated Faculty at the MGH Center for Regenerative Medicine Researchers 12 postdoctoral fellows, technicians, and students Studies The laboratory has worked to develop experimental models to better understand cholangiocarcinoma and predict potential new treatment approaches Message to Patients As a CCF Scientific Advisory Board Member and cholangiocarcinoma researcher, Dr. Bardeesy would like to convey the message to patients that there is a rapidly growing community of scientists who are focusing on this cancer. Significant advances have been made in identifying and understanding the mutations that cause this cancer. This information has led to clinical trials that are showing promise. While much more needs to be done, the basic foundations in knowledge and model systems will continue to draw investigators...

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